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Brazilian Symposium on Bioinformatics

BSB 2020: Advances in Bioinformatics and Computational Biology pp 38–49Cite as

In silico Pathogenomic Analysis of Corynebacterium Pseudotuberculosis Biovar Ovis

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Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 12558))

Abstract

Corynebacterium pseudotuberculosis is a pathogenic bacterium that may transmit caseous lymphadenitis, veterinary infection that severely attacks animals such as goats and sheep. It is known that the toxin Phosholipase D is the major virulence factor associated with this disease. However, genomic computational studies can reveal further information concerning pathogenicity mechanisms of bacteria. Through sequence analysis tools, it is possible to assess the genomic bases of these mechanisms and to analyze similarities among the different strains of this species. Nitrate reductase-negative bacteria are classified in the biovar ovis, able to transmit the infection. Thus, we developed an in silico comparative pathogenomic analysis with genomes of 33 strains of C. pseudotuberculosis biovar ovis strains, which cause caseous lymphadenitis. Looking for the identification of pathogenicity-related genes, virulence factors and composition of pathogenicity islands, it was possible to computationally predict pathogenicity potentials of target proteins and their respective biological processes during infection, besides identification of prophage genome elements and prediction of protein protein interactions.

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Authors and Affiliations

  1. Laboratory of Genomics and Bioinformatics, Center of Genomics and Systems Biology, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil

    Iago Rodrigues Blanco, Carlos Leonardo Araújo & Adriana Carneiro Folador

Authors
  1. Iago Rodrigues Blanco
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  2. Carlos Leonardo Araújo
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  3. Adriana Carneiro Folador
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Corresponding author

Correspondence to Adriana Carneiro Folador .

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Editors and Affiliations

  1. University of São Paulo, São Paulo, Brazil

    João C. Setubal

  2. Instituto Federal de Goiás, Formosa, Goiás, Brazil

    Waldeyr Mendes Silva

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Blanco, I.R., Araújo, C.L., Folador, A.C. (2020). In silico Pathogenomic Analysis of Corynebacterium Pseudotuberculosis Biovar Ovis. In: Setubal, J.C., Silva, W.M. (eds) Advances in Bioinformatics and Computational Biology. BSB 2020. Lecture Notes in Computer Science(), vol 12558. Springer, Cham. https://doi.org/10.1007/978-3-030-65775-8_4

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  • DOI: https://doi.org/10.1007/978-3-030-65775-8_4

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-65774-1

  • Online ISBN: 978-3-030-65775-8

  • eBook Packages: Computer ScienceComputer Science (R0)

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