Bioinformatics of infectious and chronic diseases at the Center for Technological Development in Health of Fiocruz
DOI:
https://doi.org/10.5753/jidm.2024.2625Keywords:
Information retrieval, Data Mining and Integration, System ModelingAbstract
One of the bioinformatics purposes is data mining and integration to solve fundamental scientific challenges. We have been investigating biological systems including viruses, bacteria, fungi, protozoans, plants, insects, and animals with such concern. Gradually, we moved from basic questions on genome organization to application in infectious and chronic diseases by integrating interactome and RNA-seq data to modeling techniques such as Flux Balance Analysis, structural modeling, Boolean modeling, system dynamics, and computation biology in a system biology perspective. At the moment, we focus on the rational therapy of cancer assisted by RNA sequencing, network modeling, and structural modeling.
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