Application of the NetLogo Tool in Ischemic Stroke Simulation
Resumo
This paper presents the proposal of a mathematical model for ischemic stroke, which is implemented with multiagent systems, in a general purpose tool known as NetLogo. The objective of this simulator is to obtain a partial view of the stroke for didactic purposes and to motivate future works for the treatment of the disease. Given the importance of stroke, we want to know how it evolves after its initial symptom, over time. This simulator allows a study of the evolution of the disease, regarding the speed of growth and the affected areas in certain region of the brain.
Referências
Adams, H. P., Del Zoppo, G., Alberts, M. J., Bhatt, D. L., Brass, L., Furlan, A., Grubb, R. L., Higashida, R. T., Jauch, E. C., Kidwell, C., et al. (2007). Guidelines for the early management of adults with ischemic stroke. Circulation, 115(20):e478–e534.
Alligood, K. T., Sauer, T. D., and Yorke, J. A. (1996). Chaos. Springer. Brasil, P. (2014). Acidente vascular cerebral (avc). http://www.brasil.gov.br/saude/2012/04/acidente-vascular-cerebral-avc. acessada: 16 de agosto de 2018.
Das, R. R., Seshadri, S., Beiser, A. S., Kelly-Hayes, M., Au, R., Himali, J. J., Kase, C. S., Benjamin, E. J., Polak, J. F., O’Donnell, C. J., et al. (2008). Prevalence and correlates of silent cerebral infarcts in the framingham offspring study. Stroke, 39(11):2929–2935.
Di Russo, C., Lagaert, J.-B., Chapuisat, G., and Dronne, M.-A. (2010). A mathematical model of inflammation during ischemic stroke. In ESAIM: Proceedings, volume 30, pages 15–33. EDP Sciences.
dos Santos Ferreira Silva, P. (2008). Uma introdução ao estudo de sistemas dinâmicos discretos.
Dronne, M.-A., Boissel, J.-P., Grenier, E., Gilquin, H., Cucherat, M., Hommel, M., Barbier, E., and Bricca, G. (2004). Mathematical modelling of an ischemic stroke: an integrative approach. Acta biotheoretica, 52(4):255–272.
Lelekov-Boissard, T., Chapuisat, G., Boissel, J.-P., Grenier, E., and Dronne, M.-A. (2009). Exploration of beneficial and deleterious effects of inflammation in stroke: dynamics of inflammation cells. Philosophical Transactions of the Royal Society of
London A: Mathematical, Physical and Engineering Sciences, 367(1908):4699–4716.
Norvig, P. and Russell, S. (2014). Inteligência artificial, 3a edição.
Nunes, R. R. (2010). Sistemas dinâmicos discretos lineares. Universidade Federal de Minas Gerais.
Perreira, C. C. (2016). Avc isquêmico: sintomas, tratamentos e causas. http://www.minhavida.com.br/saude/temas/avc-isquemico. acessada: 16 de agosto de 2018.
Storini, C., Rossi, E., Marrella, V., Distaso, M., Veerhuis, R., Vergani, C., Bergamaschini L., and De Simoni, M.-G. (2005). C1-inhibitor protects against brain ischemia– reperfusion injury via inhibition of cell recruitment and inflammation. Neurobiology of disease, 19(1):10–17.
Villate, J. E. (2011). Introdução aos sistemas dinâmicos: uma abordagem prática com maxima.
Warlow, C. P., Dennis, M. S., van Gijn, J., Hankey, G. J., Sandercock, P. A., Bamford, J. M., and Wardlaw, J. M. (2001). Stroke: a practical guide to management. Wiley- Blackwell.