Modelagem Computacional do Crescimento Cerebral Utilizando a Teoria do Crescimento Finito
Resumo
O dobramento cortical é crucial para o desenvolvimento cerebral, e alterações nesse processo podem gerar distúrbios neurológicos, evidenciando sua relevância clínica, como em casos de microcefalia associada ao vírus Zika. Estudos indicam que mecanismos mecânicos desempenham papel fundamental nesse fenômeno. Este trabalho investiga a influência de parâmetros físicos na formação de sulcos e giros por meio de um modelo computacional baseado na mecânica do contínuo e na teoria do crescimento finito, resolvido via elementos finitos. Os resultados concordam com a literatura, indicando a influência mecânica no dobramento cortical e que, no contexto do Zika, a redução do crescimento cortical levou a padrões semelhantes à microcefalia.Referências
Budday, S., Raybaud, C., and Kuhl, E. (2014a). A mechanical model predicts morphological abnormalities in the developing human brain. Scientific reports, 4(1):5644.
Budday, S., Steinmann, P., and Kuhl, E. (2014b). The role of mechanics during brain development. Journal of the Mechanics and Physics of Solids, 72:75–92.
Group, M. E. R. (2016). Microcephaly in infants, Pernambuco state, Brazil, 2015. Emerging infectious diseases, 22(6):1090.
Guimarães, A. P. R. (2025). Modelagem computacional do crescimento cerebral utilizando a teoria do crescimento finito. Dissertação (mestrado em modelagem computacional), Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil.
Hatten, M. E. (1999). Central nervous system neuronal migration. Annual Review of Neuroscience, 22(1):511–539.
Holzapfel, G. A. (2002). Nonlinear solid mechanics: a continuum approach for engineering science.
INTERGROWTH-21st (2014). International fetal and newborn growth consortium for the 21st century (INTERGROWTH-21st). international standards for newborn weight, length, and head circumference by gestational age and sex: the newborn cross-sectional study of the intergrowth-21st project.
Kuhl, E. (2014). Growing matter: a review of growth in living systems. Journal of the Mechanical Behavior of Biomedical Materials, 29:529–543.
Rakic, P. (1988). Specification of cerebral cortical areas. Science, 241(4862):170–176.
Rodriguez, E. K., Hoger, A., and McCulloch, A. D. (1994). Stress-dependent finite growth in soft elastic tissues. Journal of biomechanics, 27(4):455–467.
Ronan, L., Voets, N., Rua, C., Alexander-Bloch, A., Hough, M., Mackay, C., Crow, T. J., James, A., Giedd, J. N., and Fletcher, P. C. (2014). Differential tangential expansion as a mechanism for cortical gyrification. Cerebral Cortex, 24(8):2219–2228.
Taber, L. A. (1995). Biomechanics of growth, remodeling, and morphogenesis.
Wang, L., Yao, J., and Hu, N. (2019). A mechanical method of cerebral cortical folding development based on thermal expansion. Scientific Reports, 9(1):1914.
Zilles, K., Armstrong, E., Schleicher, A., and Kretschmann, H.-J. (1988). The human pattern of gyrification in the cerebral cortex. Anatomy and embryology, 179:173–179.
Budday, S., Steinmann, P., and Kuhl, E. (2014b). The role of mechanics during brain development. Journal of the Mechanics and Physics of Solids, 72:75–92.
Group, M. E. R. (2016). Microcephaly in infants, Pernambuco state, Brazil, 2015. Emerging infectious diseases, 22(6):1090.
Guimarães, A. P. R. (2025). Modelagem computacional do crescimento cerebral utilizando a teoria do crescimento finito. Dissertação (mestrado em modelagem computacional), Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil.
Hatten, M. E. (1999). Central nervous system neuronal migration. Annual Review of Neuroscience, 22(1):511–539.
Holzapfel, G. A. (2002). Nonlinear solid mechanics: a continuum approach for engineering science.
INTERGROWTH-21st (2014). International fetal and newborn growth consortium for the 21st century (INTERGROWTH-21st). international standards for newborn weight, length, and head circumference by gestational age and sex: the newborn cross-sectional study of the intergrowth-21st project.
Kuhl, E. (2014). Growing matter: a review of growth in living systems. Journal of the Mechanical Behavior of Biomedical Materials, 29:529–543.
Rakic, P. (1988). Specification of cerebral cortical areas. Science, 241(4862):170–176.
Rodriguez, E. K., Hoger, A., and McCulloch, A. D. (1994). Stress-dependent finite growth in soft elastic tissues. Journal of biomechanics, 27(4):455–467.
Ronan, L., Voets, N., Rua, C., Alexander-Bloch, A., Hough, M., Mackay, C., Crow, T. J., James, A., Giedd, J. N., and Fletcher, P. C. (2014). Differential tangential expansion as a mechanism for cortical gyrification. Cerebral Cortex, 24(8):2219–2228.
Taber, L. A. (1995). Biomechanics of growth, remodeling, and morphogenesis.
Wang, L., Yao, J., and Hu, N. (2019). A mechanical method of cerebral cortical folding development based on thermal expansion. Scientific Reports, 9(1):1914.
Zilles, K., Armstrong, E., Schleicher, A., and Kretschmann, H.-J. (1988). The human pattern of gyrification in the cerebral cortex. Anatomy and embryology, 179:173–179.
Publicado
01/06/2026
Como Citar
GUIMARÃES, Alexsandro Pattiele Rosa; BASTOS, Flávia de Souza; ROCHA, Bernardo Martins.
Modelagem Computacional do Crescimento Cerebral Utilizando a Teoria do Crescimento Finito. In: PRÊMIO ARTUR ZIVIANI - CONCURSO DE TESES E DISSERTAÇÕES (MESTRADO) - SIMPÓSIO BRASILEIRO DE COMPUTAÇÃO APLICADA À SAÚDE (SBCAS), 26. , 2026, Ouro Preto/MG.
Anais [...].
Porto Alegre: Sociedade Brasileira de Computação,
2026
.
p. 115-120.
ISSN 2763-8987.
DOI: https://doi.org/10.5753/sbcas_estendido.2026.21178.
