Controle de Regimes de Dosagens e Ajuste de Parâmetros Farmacocinéticos
Resumo
Este trabalho propõe um software para a previsão e registro de regimes de dosagens de substâncias terapêuticas, simulação de curvas de concentração e ajuste dos parâmetros farmacocinéticos de pacientes. A proposta desenvolvida utiliza dados de pacientes fornecidos por especialistas na área. O software desenvolvido, gerencia dados de pacientes, simula o comportamento farmacocinético de um fármaco em um tratamento e aplica o método Bayesiano para individualização das dosagens de fármacos. Após testar a solução desenvolvida e compará-la com outros softwares já adotados por acadêmicos e profissionais da farmacologia, verificou-se que os resultados obtidos são promissores.
Referências
BAUER, Larry A. Applied Clinical Pharmacokinetics. [Nova Iorque]: McGraw-Hill Education, 3 ed. 2014.
FUCHS, Aline; CSAJKA, Chantal; THOMA, Yann; BUCLIN, Thierry; WIDMER, Nicolas. Benchmarking Therapeutic Drug Monitoring Software: A Review of Available Computer Tools, Clinical Pharmacokinetics, v. 52, n. 1, p. 9-22, jan. 2013.
MEHVAR, Reza. Pharmacokinetic-based design and modification of dosage regimens. American Journal of Pharmaceutical Education, Des Moines, v. 63, n. 2, p. 189-195, 1998.
MOULD, Dr.; UPTON, Rn. Basic Concepts in Population Modeling, Simulation, and Model-Based Drug Development, CPT Pharmacometrics & Systems Pharmacology, v.1, n. 9, ed. 6, 2012.
PROOST, Johannes H.; MEIJER, Dirk K. F. MW/Pharm, an integrated software package for drug dosage regimen calculation and therapeutic drug monitoring. Computers in Biology and Medicine, v. 22, n. 3, p. 155-163, may. 1992.
SHEINER, Lewis B.; BEAL, Stuart L. Bayesian individualization of pharmacokinetics: Simple implementation and comparison with non-Bayesian methods, Journal of Pharmaceutical Sciences, Nova Iorque, v. 17, n. 12, p. 1344-1348, dez. 1982.
SHEINER, Lewis B.; BEAL, Stuart; ROSENBERG, Barr; MARATHE, Vinay V. Forecasting individual pharmacokinetics. Clinical Pharmacology & Therapeutics, v. 26, n. 3, p. 294-305, set. 1979.
WINTER, Michael E. Basic Clinical Pharmacokinetics. Baltimore: Lippincott Williams & Wilkins, 4 e. 2004.
FUCHS, Aline; CSAJKA, Chantal; THOMA, Yann; BUCLIN, Thierry; WIDMER, Nicolas. Benchmarking Therapeutic Drug Monitoring Software: A Review of Available Computer Tools, Clinical Pharmacokinetics, v. 52, n. 1, p. 9-22, jan. 2013.
MEHVAR, Reza. Pharmacokinetic-based design and modification of dosage regimens. American Journal of Pharmaceutical Education, Des Moines, v. 63, n. 2, p. 189-195, 1998.
MOULD, Dr.; UPTON, Rn. Basic Concepts in Population Modeling, Simulation, and Model-Based Drug Development, CPT Pharmacometrics & Systems Pharmacology, v.1, n. 9, ed. 6, 2012.
PROOST, Johannes H.; MEIJER, Dirk K. F. MW/Pharm, an integrated software package for drug dosage regimen calculation and therapeutic drug monitoring. Computers in Biology and Medicine, v. 22, n. 3, p. 155-163, may. 1992.
SHEINER, Lewis B.; BEAL, Stuart L. Bayesian individualization of pharmacokinetics: Simple implementation and comparison with non-Bayesian methods, Journal of Pharmaceutical Sciences, Nova Iorque, v. 17, n. 12, p. 1344-1348, dez. 1982.
SHEINER, Lewis B.; BEAL, Stuart; ROSENBERG, Barr; MARATHE, Vinay V. Forecasting individual pharmacokinetics. Clinical Pharmacology & Therapeutics, v. 26, n. 3, p. 294-305, set. 1979.
WINTER, Michael E. Basic Clinical Pharmacokinetics. Baltimore: Lippincott Williams & Wilkins, 4 e. 2004.
Publicado
22/07/2018
Como Citar
EBERTZ, Vitor F.; CARVALHO, Juliano V.; GOULART, Rodrigo; MONTICELLI, Cíntia O.; LINDEN, Rafael.
Controle de Regimes de Dosagens e Ajuste de Parâmetros Farmacocinéticos. In: SIMPÓSIO BRASILEIRO DE COMPUTAÇÃO APLICADA À SAÚDE (SBCAS), 18. , 2018, Natal.
Anais [...].
Porto Alegre: Sociedade Brasileira de Computação,
2018
.
p. 195-204.
ISSN 2763-8952.
DOI: https://doi.org/10.5753/sbcas.2018.3694.
