Modelagem computacional da resposta imune à vacina contra febre amarela

• Carla R. B. Bonn UFJF
• Guilherme C. Fernandes UFJF
• Rodrigo W. Santos UFJF
• Marcelo Lobosco UFJF

DOI: https://doi.org/10.5753/sbcas.2020.11555

Abstract

An effective yellow fever vaccine has been available since 1937. Nevertheless, questions regarding its use remain poorly understood, such as the ideal dose to confer immunity against the disease, the need for booster dose, the optimal immunization schedule for immunocompetent, immunosuppressed, and children, among other issues. This work presents a computational model of the human immune response to vaccination against yellow fever that was able to replicate the levels of antibodies obtained experimentally in different vaccination scenarios, allowing a quantitative validation with experimental data. Some behaviors of the immune response described in the literature were also reproduced qualitatively.

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