Permissioned Blockchain Architecture for Web 3.0 Applications: Use Case in Healthcare Transfer
Abstract
This paper presents a permissioned blockchain-based architecture that advances both the scientific understanding and practical implementation of distributed healthcare solutions in Web 3.0 contexts. Unlike approaches that address technologies such as blockchain, AI, edge computing, and immersive environments in isolation, this study integrates them to tackle challenges in transfer of care (also known as transitional care) scenarios. It proposes a hybrid onchain/off-chain architecture that ensures traceability, governance, and security across institutions. The solution incorporates digital twins, AR/VR interfaces, and 5G/Wi-Fi 6E connectivity to support real-time clinical decision-making and enrich interactions between patients and healthcare professionals. The Proof of Concept (PoC) demonstrates how a permissioned blockchain can optimize auditing, reduce reliance on intermediaries, and enable decentralized data management. The analysis indicates that the proposed architecture contributes to building safer and more transparent healthcare systems.
Keywords:
Permissioned Blockchain, Web 3.0, Digital Twins, Augmented Reality, Virtual Reality, Edge Computing, Digital Health, Clinical Data Tracking, Healthcare Transfer
References
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Androulaki, E., Barger, A., Bortnikov, V., Cachin, C., Christidis, K., Caro, A. D., Enyeart, D., Ferris, C., Laventman, G., Manevich, Y., Muralidharan, S., Murthy, C., Nguyen, B., Sethi, M., Singh, G., Smith, K., Sorniotti, A., Stathakopoulou, C., Vukolić, M., Cocco, S. W., & Yellick, J. (2018). Hyperledger Fabric: A distributed operating system for permissioned blockchains. EuroSys 18, 30:1–30:15. ACM.
Antwi, M., Adnane, A., Ahmad, F., Hussain, R., Habib ur Rehman, M., & Kerrache, C. A. (2021). The case of Hyperledger Fabric as a blockchain solution for healthcare applications. Blockchain: Research and Applications, 2(1), 100012.
Chengoden, R., Victor, N., Huynh-The, T., Yenduri, G., Jhaveri, R. H., Alazab, M., Bhattacharya, S., Hegde, P., Maddikunta, P. K. R., & Gadekallu, T. R. (2023). Metaverse for healthcare: A survey on potential applications, challenges and future directions. IEEE Access, 11, 12765–12795.
Eren, H., Karaduman, O., & Gençoğlu, M. T. (2025). Security challenges and performance trade-offs in on-chain and off-chain blockchain storage: A comprehensive review. Applied Sciences, 15(6).
Guimarães, T., Silva, H., Peixoto, H., & Santos, M. (2020). Modular blockchain implementation in intensive medicine. Procedia Computer Science, 170, 1059–1064.
Jameil, A. K., & Al-Raweshidy, H. (2024). A digital twin framework for real-time healthcare monitoring: Leveraging AI and secure systems for enhanced patient outcomes. Research Square.
Mello, T. S. d., Miorin, J. D., Camponogara, S., Paula, C. C. d., Pinno, C., & Freitas, E. d. O. (2021). Factors that influence effective intra-hospital care transfer: Integrative review. Research, Society and Development, 10(9), e38910918153.
Muzaffar, M. S. P. A., Afianti, F., & Rokatenda, E. B. (2024). Implementation and performance analysis of non-blockchain-based and blockchain-based business licensing systems using Hyperledger Fabric. The Indonesian Journal of Computer Science, 13(5).
Narayan, A., Weng, K., & Shah, N. (2024). Decentralizing healthcare: History and opportunities of Web3. JMIR Form Res, 8, e52740.
Pandey, A. K., Khan, A. I., Abushark, Y. B., Alam, M. M., Agrawal, A., Kumar, R., & Khan, R. A. (2020). Key issues in healthcare data integrity: Analysis and recommendations. IEEE Access, 8, 40612–40628.
Rane, N., Choudhary, S., & Rane, J. (2023). Enhanced product design and development using artificial intelligence (AI), virtual reality (VR), augmented reality (AR), 4D/5D/6D printing, internet of things (IoT), and blockchain: A review. SSRN Electronic Journal, 1–33.
Raso, E., Loreti, P., Ravaziol, M., & Bracciale, L. (2024). Anonymization and pseudonymization of FHIR resources for secondary use of healthcare data. IEEE Access, 12, 44929–44939.
Rowan, N. J. (2024). Digital technologies to unlock safe and sustainable opportunities for medical device and healthcare sectors with a focus on the combined use of digital twin and extended reality applications: A review. Science of The Total Environment, 926, 171672.
Satybaldy, A., Hasselgren, A., & Nowostawski, M. (2022). Decentralized identity management for e-health applications: State-of-the-art and guidance for future work. Blockchain in Healthcare Today, 5.
Siddiqi, S. J., Saleh, S., Jan, M. A., & Tariq, M. (2025). Securing the vetaverse: Web 3.0 for decentralized digital twin-enhanced vehicle–road safety. Future Generation Computer Systems, 164, 107555.
Singh, S. K., Rathore, S., & Park, J. H. (2020). BlockIoTIntelligence: A blockchain-enabled intelligent IoT architecture with artificial intelligence. Future Generation Computer Systems, 110, 721–743.
Song, Y.-T., & Qin, J. (2022). Metaverse and personal healthcare. Procedia Computer Science, 210, 189–197.
Vasiliu-Feltes, I., Mylrea, M., Zhang, C. Y., Wood, T.-C., & Thornley, B. (2023). Impact of blockchain-digital twin technology on precision health, pharmaceutical industry, and life sciences: Conference proceedings, CONV2X 2023. Blockchain in Healthcare Today, 6. Acesso em: 24 mar. 2025.
Published
2025-05-19
How to Cite
HONÓRIO DA SILVA, Matheus Lázaro; DE LIMA, Eliomar Araújo; COSTA, Fábio M.; CARVALHO, Sergio T.; GRACIANO-NETO, Valdemar Vicente.
Permissioned Blockchain Architecture for Web 3.0 Applications: Use Case in Healthcare Transfer. In: BLOCKCHAIN WORKSHOP: THEORY, TECHNOLOGY AND APPLICATIONS (WBLOCKCHAIN), 8. , 2025, Natal/RN.
Anais [...].
Porto Alegre: Sociedade Brasileira de Computação,
2025
.
p. 168-181.
DOI: https://doi.org/10.5753/wblockchain.2025.9508.
