Estudos in silico ADME para uma série de inibidores da enzima conversora da angiotensina (ECA)

• Yuri Rayel Fernandes de Sousa IFPI
• Joaquim S. da Costa Júnior IFPI
• Danielle da Costa Silva IFPI

DOI: https://doi.org/10.5753/sbcas.2021.16085

Abstract

Arterial hypertension is considered the main factor of morbimortality in the world, and it is necessary to explore other forms of treatment that accessible more and that allow an effective blockade of the related pathophysiological mechanism. Thus, the main objective of the present work is to evaluate the pharmacokinetic parameters of in silico metabolization for molecules derived from triazolones and bis-triazolones that inhibit the angiotensin-converting enzyme (ACE). The parameters were analyzed using the PreADMET program. The results obtained are unprecedented and show that the selected compounds have considerable properties for inhibiting CYP enzymes.

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