Development of a Methodology for Comorbidity Gene Analysis Based on Epidemiological Data Integration

• Karla F. Neto USP
• Victor E. F. Ferraz USP
• Domingos Alves USP
• Evandro E. S. Ruiz USP

Abstract

The identification of genes responsible for human diseases provides knowledge of pathological and physiological mechanisms that are essential for the development of new diagnostics and therapeutics. We know that a disease is rarely a consequence of an abnormality in a single gene, but reflects disorders in an intra and intercellular network. In this project we analyze records of comorbidities, found genes related to these diseases and evaluate whether this genes correspond to the incidence of those pairs of diseases.

References

Barabási A, Gulbahce N, Loscalzo J. (2011). Nature Reviews. Network medicine: a network-based approach to human disease.

Goh K-I, Cusick ME, et al. (2007) The human disease network. Proc Natl Acad Sci U S A 104: 8685–8690.

Lee DS, Park J, et al. (2008) The implications of human metabolic network topology for disease comorbidity. Proc Natl Acad Sci U S A 105: 9880–9885.

Grosen D, Bille C, et al. 2011. Risk of oral clefts in twins. Epidemiol 22:313–319.

Roque FS, Jensen PB, et al. (2011) Using Electronic Patient Records to Discover Disease Correlations and Stratify Patient Cohorts.

Definição UMLS: [link]. Último acesso em 7 de abril, 2012.

Definição Metamap: [link] acesso em 7 de abril, 2012.