Use of the Ontocancer Ontology to Validate the Involvement of Genes with Cancer Progression Barrier

• Laís Falcade UFSM
• Karlise Soares UFSM
• Karine de Souza UFSM
• Eder Simão UFSM
• José Carlos Marino Mombach UFSM
• Giovani Rubert Librelotto UFSM

Abstract

An important question involving the study of the human genome refers to research into the expression of genes involved in cancer formation. The Ontocancro 2.0 was developed to assist with this task and provide data integration related to pathways of genome maintenance mechanisms (GMM). Allied to it is an algorithm for statistical analysis of the values of diversity and relative activity. The purpose of this article is to demonstrate how Ontocancro can demonstrate quantitatively the results obtained by studies that describe a barrier to progress of cancer in precancerous lesions.

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