Applying Ventricular Wall Shape and Motion Features from CMRI for Aiding Diagnosis of Cardiomyopathies

  • Stephani S. H. Costa USP
  • Vagner Mendonça Gonçalves USP / IFSP
  • Fátima L. S. Nunes USP

Resumo


Cardiomyopathies are diseases usually characterized by dilation or hypertrophy of the heart muscle. Left Ventricle (LV) is the heart chamber most affected in most cases. Cardiac Cine Magnetic Resonance Imaging (CMRI) is a powerful tool applied for diagnosis of cardiomyopathies. Although some studies define descriptors based on CMRI images, usually they are related to clinical metrics. In this paper, we explored shape and motion features from the LV ventricular wall to define descriptors based on a priori knowledge about heart anomalies to build Supervised Machine Learning-based classification models capable of discriminating cases of dilated cardiomyopathy, hypertrophic cardiomyopathy, or those ones without anomalies associated with these diseases. The best classification model built and evaluated achieved F1-score = 0.85± 0.05, accuracy = 0.85± 0.04, and AUC = 0.94± 0.02. Our results are promising, indicating the potential of the approach for applications in computer-aided diagnosis systems.

Palavras-chave: Cardiac Cine Magnetic Resonance Imaging, CMRI, Shape Features, Motion Features, Supervised Machine Learning, Left Ventricle, Ventricular Wall, Computer-Aided Diagnosis, Dilated Cardiomyopathy, Hypertrofic Cardiomyopathy

Referências

Ammar, A., Bouattane, O., and Youssfi, M. (2021). Automatic cardiac cine MRI segmentation and heart disease classification. Comput. Med. Imaging Graph., 88.

Antonopoulos, A. S., Boutsikou, M., Simantiris, S., Angelopoulos, A., and et al. (2021). Machine learning of native T1 mapping radiomics for classification of hypertrophic cardiomyopathy phenotypes. Sci. Rep., 11(1).

Bergamasco, L. C. C., Lima, K. R. P. S., Rochitte, C. E., and Nunes, F. L. S. (2022). A bipartite graph approach to retrieve similar 3D models with different resolution and types of cardiomyopathies. Expert Syst. Appl., 193.

Bhatia, D., Kanakatte, A., and Ghose, A. (2022). Cardiac anomaly detection from cine MRI images using physiological features and random forest classifier. In Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. IEEE.

Bishop, C. M. (2006). Pattern Recognition and Machine Learning. Springer, New York, 1 edition.

Braunwald, E. (2017). Cardiomyopathies: an overview. Circ. Res., 121(7).

Chawla, N. V., Bowyer, K. W., Hall, L. O., and Kegelmeyer, W. P. (2002). SMOTE: Synthetic Minority Over-Sampling Technique. J. Artif. Intell. Res., 16(1).

Delmondes, P. H. M. (2022). Sistemas de auxílio ao diagnóstico de cardiomiopatias: uma abordagem baseada em descritores multi-slice e multi-frame. Dissertação, Escola de Artes, Ciências e Humanidades, Universidade de São Paulo. [In Portuguese].

Elliott, P. M., Anastasakis, A., Borger, M. A., Borggrefe, M., and et al. (2014). 2014 ESC guidelines on diagnosis and management of hypertrophic cardiomyopathy: the task force for the diagnosis and management of hypertrophic cardiomyopathy of the European Society of Cardiology (esc). Eur. Heart J., 35(39).

Hastie, T., Tibshirani, R., and Friedman, J. (2009). The Elements of Statistical Learning. Springer, 2 edition.

Heiberg, E., Sjögren, J., Ugander, M., Carlsson, M., Engblom, H., and Arheden, H. (2010). Design and validation of Segment freely available software for cardiovascular image analysis. BMC Med. Imaging, 10(1).

Izquierdo, C., Casas, G., Martin-Isla, C., Campello, V. M., and et al. (2021). Radiomics-based classification of left ventricular non-compaction, hypertrophic cardiomyopathy, and dilated cardiomyopathy in cardiovascular magnetic resonance. Front. Cardiovasc. Med., 8.

Kumar, V., Abbas, A. K., and Aster, J. C. (2020). Robbins & Cotran, Pathologic Basis of Disease. Elsevier, 10 edition.

Lemaître, G., Nogueira, F., and Aridas, C. K. (2017). Imbalanced-learn: a Python toolbox to tackle the curse of imbalanced datasets in machine learning. J. Mach. Learn. Res., 18(17).

Liu, Q., Lu, Q., Chai, Y., Tao, Z., Wu, Q., Jiang, M., and Pu, J. (2023). Papillary-muscle-derived radiomic features for hypertrophic cardiomyopathy versus hypertensive heart disease classification. Diagnostics, 13(9).

MacFarland, T. W. and Yates, J. M. (2016). Mann–Whitney U test. In MacFarland, T. W. and Yates, J. M., editors, Introduction to Nonparametric Statistics for the Biological Sciences Using R, pages 103–132. Springer, Cham, 1 edition.

Manning, C. D., Raghavan, P., and Schütze, H. (2008). Introduction to Information Retrieval. Cambridge University Press, Cambridge.

Maron, B. J., Towbin, J. A., Thiene, G., Antzelevitch, C., and et al. (2006). Contemporary definitions and classification of the cardiomyopathies: an American Heart Association scientific statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology interdisciplinary working groups; and Council on Epidemiology and Prevention. Circulation, 113(14).

Martin, S. S., Aday, A. W., Almarzooq, Z. I., Anderson, C. A. M., and et al. (2024). 2024 heart disease and stroke statistics: a report of US and global data from the American Heart Association. Circulation, 149(8).

Menchón-Lara, R. M., Wattenberg, F. S., Higuera, P. C., Fernández, M. M., and López, C. A. (2019). Reconstruction techniques for cardiac cine MRI. Insights Imaging, 10.

Moreno, A., Rodriguez, J., and Martínez, F. (2019). Regional multiscale motion representation for cardiac disease prediction. In Symp. Image Signal Process. Artif. Vis. IEEE.

Neisius, U., El-Rewaidy, H., Nakamori, S., Rodriguez, J., Manning, W. J., and Nezafat, R. (2019). Radiomic analysis of myocardial native T1 imaging discriminates between hypertensive heart disease and hypertrophic cardiomyopathy. JACC: Cardiovasc. Imaging, 12(10).

Pedregosa, F., Varoquaux, G., Gramfort, A., Michel, V., and et al. (2011). Scikit-learn: machine learning in Python. J. Mach. Learn. Res., 12(85).

Peña, H., Gómez, S., Romo-Bucheli, D., and Martinez, F. (2021). Cardiac disease representation conditioned by spatio-temporal priors in cine-MRI sequences using generative embedding vectors. In Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. IEEE.

Rasmussen, C. E. and Nickisch, H. (2010). Gaussian processes for machine learning (GPML) toolbox. J. Mach. Learn. Res., 11.

Snaauw, G., Gong, D., Maicas, G., van den Hengel, A., Niessen, W. J., Verjans, J., and Carneiro, G. (2019). End-to-end diagnosis and segmentation learning from cardiac magnetic resonance imaging. In IEEE Int. Symp. Biomed. Imaging. IEEE.

Stone, M. (1974). Cross-validatory choice and assessment of statistical predictions. J. R. Stat. Soc., 36(2):111–133.

Waite, S., Kolla, S., Jeudy, J., Legasto, A., Macknik, S. L., Martinez-Conde, S., Krupinski, E. A., and Reede, D. L. (2017). Tired in the reading room: the influence of fatigue in Radiology. J. Am. Coll. Radiol., 14(2).

Whiteman, S., Alimi, Y., Carrasco, M., Gielecki, J., Zurada, A., and Loukas, M. (2021). Anatomy of the cardiac chambers: a review of the left ventricle. Transl. Res. Anat., 23.

Xiao, J., Liu, X., Tao, Q., and Chen, J. (2020). Learning motion based auxiliary task for cardiomyopathy recognition with cardiac magnetic resonance images. In Int. Conf. Comput. Sci. Appl. Eng.

You, Y., Viktorovich, L. A., Qiu, J., Nikolaevich, K. A., and Vladimirovich, B. Y. (2021). Cardiac magnetic resonance image diagnosis of hypertrophic obstructive cardiomyopathy based on a double-branch neural network. Comput. Methods Programs Biomed., 200.

Zhang, X., Cui, C., Zhao, S., Xie, L., and Tian, Y. (2023). Cardiac magnetic resonance radiomics for disease classification. Eur. Radiol., 33(4).
Publicado
25/06/2024
COSTA, Stephani S. H.; GONÇALVES, Vagner Mendonça; NUNES, Fátima L. S.. Applying Ventricular Wall Shape and Motion Features from CMRI for Aiding Diagnosis of Cardiomyopathies. In: SIMPÓSIO BRASILEIRO DE COMPUTAÇÃO APLICADA À SAÚDE (SBCAS), 24. , 2024, Goiânia/GO. Anais [...]. Porto Alegre: Sociedade Brasileira de Computação, 2024 . p. 142-153. ISSN 2763-8952. DOI: https://doi.org/10.5753/sbcas.2024.2066.

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